The Clinical Chemistry learning guide focuses on clinical chemistry, which encompasses a wide variety of tests and is a major area of concentration in hospital and reference core laboratories. Clinical chemistry uses many different methodologies, manual and fully automated tests, examines both very common and esoteric analytes, mixes basic chemistry with biochemistry, engineering, informatics andother disciplines, and overlaps with other areas of concentration, in particular, toxicology and endocrinology.
The Proteins learning guide is an overview of the pathophysiological principles and the major disease states related to important serum proteins. It provides an understanding of clinically important serum proteins and their use in diagnosing and managing common clinical situations. It reviews the different important analytical techniques used to identify and quantify these proteins. It also describes approaches to standardizing or harmonizing protein assays. The guide is intended to be used as a reference for the application of clinical laboratory tests and interpretation of laboratory results.
The Therapeutic Drug Monitoring learning guide provides an overview of drug concentration measurements in body fluids as an aid to management of drug therapy for the cure, alleviation or prevention of disease. It has long been customary to adjust the dosage of drugs according to the characteristics of the individual being treated and the response obtained. Therapeutic Drug Monitoring now has an established place in enabling optimization of therapy with certain agents.Download (PDF, 3 MB)
Chronic Kidney Disease (CKD), one form of kidney dysfunction, is increasingly recognized as a major public health concern. The continuum of CKD ranges from mild kidney damage to end-stage renal disease (ESRD). Early detection and appropriate management can help delay progression to kidney failure and the development of complications.
Diagnosis of CKD is based on laboratory criteria and has important implications for patients, with emotional, pharmacological, and socioeconomic impact. New practice guidelines and the standardization of renal function tests offer an opportunity to greatly improve the health of CKD patients and reduce the cost of care.
The Shedding Light on Renal Disease monograph describes the incidence and physiology of CKD and associated complications, diagnostic guidelines and tests, and laboratory assessment of renal function.
The CKD learning guide provides an overview of chronic kidney disease and explains the complications, diagnosis and management of the disease.
The Six Sigma Based Quality Control learning guide provides the basics of statistical quality control (SQC) in a laboratory. SQC is an essential laboratory practice to ensure reported test results achieve the quality required for intended medical use. Analytical quality demands continue to increase as physicians and patients depend on test results for optimal diagnosis and treatment. Although modern highly automated systems provide many function checks to ensure proper operations to produce accurate results, no analytical system is perfectly stable. Laboratories need SQC to provide a final independent check to detect performance changes potentially causing medical errors.Download (PDF, 3 MB)
The Diabetes learning guide offers an overview of diabetes and the use of glycated hemoglobin (HbA1c) as a clinical tool for general health screening and monitoring for patients suspected of having diabetes. This learning guide reviews reference methodologies, available assay methods, standardization and certification. It also reviews the physiology of HbA1c and its hemoglobin variants or derivatives, and the recommendations/precautions for using HbA1c in clinical practice.Download (PDF, 5 MB)
The Thyroid Learning Guide serves the basic educational needs of health care professionals associated with thyroid function testing. Thyroid disease is the most prevalent endocrine disorder known. The onset of thyroid disease is often misunderstood by the patient. This is because the clinical manifestations of thyroid dysfunction vary considerably among patients in their characteristics and severity. Successful diagnosis and management of thyroid disease requires close collaboration between the physician, clinical laboratory and the patient. This guide provides an overview of thyroid gland function and the diseases and treatments associated with thyroid gland dysfunction.Download (PDF, 1 MB)
The Hematology Learning Guide is an overview of blood physiology, red and white blood cells, platelets and abnormalities associated with these cellular components. The Full Blood Count (FBC) encompasses a wide variety of hematology tests and is commonly requested in hospital and reference core laboratories. The guide discusses the tests that are part of automated hematology screening as well as the different methodologies used to analyze or calculate the results. It also provides additional information regarding the clinical implications of the test results that may also require additional follow-up testing.Download (PDF, 2 MB)
(PDF, 2 MB)
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