A Real Risk

Biotin Interference with Laboratory Tests Is More Than Just An Inconvenience, It Can Pose A Real Risk to Patients

Biotin Basics

Biotin, or vitamin B7, is a water-soluble and essential B-vitamin. It is safe and healthy, and can be found in a wide range of foods that are high in protein, like meat, dairy produts, and vegetables. A typical adult's diet probably contains the recommended daily intake, an average of 30-40 μg per day (with variation).1 Biotin can also be found in multivitamins, prenatal vitamins, and supplements for hair, skin and nails. Higher doses of biotin are being recommended by physicians for variuos medical conditions.


Increase in Use: 52% Increase In Biotin Sales
Over 4 Years

Biotin use is on the rise. Recent changes in consumer use and clinical practice have contributed to an increased prevalence of biotin use.2

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Why Is Biotin A Concern? Increase in Adverse Events Reported to FDA

Biotin interference poses a risk to laboratory tests that incorporate the free biotin-streptavidin capture method. We know the risk is real, as there has been an increase in the number of adverse events reported to the FDA associated with biotin interference with laboratory tests.3

Biotin Increase in Test Interference Graph Image
Data from US FDA Manufacturer and User Facility Device Experience database. The MAUDE database houses medical device reports submitted to the FDA by mandatory reporters (manufacturers, importers and device user facilities) and voluntary reporters such as health care professionals, patients and cunsumers. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/search.cfm   
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See For Yourself
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Learn More About Biotin Interference

Read the FDA Safetly Communication. Biotin interference with laboratory tests has been documented in scientific literature, with examples of clinically misleading test results and misdiagnoses. The FDA has seen an increase in the number of reported adverse events, including one death, related to biotin interference with laboratory tests.4-5

Read the journal article from the Endocrine Society for an example of how biotin interference led to unnecessary diagnostic tests, creating clinical confusion and nearly causing unneeded surgery. Understand the risk.6

Ask for Abbott Tests

Fortunately, you have a choice. Not all laboratory test methods are the same. Abbott tests are biotin-interference-free. Request a test that is biotin-interference-free. Have confidence in your test results. 

For Consumers
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Learn About Biotin and how to avoid biotin-related issues

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For Physicians
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Order Lab Tests You Can Rely On for clinical decision-making

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For Laboratory Professionals
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Provide Test Results That Are biotin-interference-Free

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  1. Zempleni J, Kuroishi T. Biotin. Adv. Nutr. 3: 213–214, 2012.
  2. Nielsen, Biotin Monthly Sales Data, 2014-2017.
  3. US FDA Manufacturer and User Facility Device Experience (MAUDE) database. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/search.cfm
  4. Food and Drug Adminstration. Biotin (Vitamin B7): Safety Communication - May Interfere with Lab Tests. (January 1, 2018). https://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm586641.htm
  5. The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication (November 28, 2017) https://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm586505.htm.  
  6. Stieglitz, et. al. Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements. Journal of the Endocrine Society, Volume 2, Issue 6, 1 June 2018, Pages 563–569, https://doi.org/10.1210/js.2018-00069

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